Our research program combines several complementary initiatives, including (a) development of new catalytic reactions of broad synthetic utility; (b) synthesis of complex natural products of notable biological significance; and (c) generation of highly diverse chemical libraries, featuring the complexity of natural metabolites. The main emphasis of our laboratory is on the development of an arsenal of new methods, strategies and concepts of immediate synthetic utility. Our parallel objective is to coordinate a broad multidisciplinary effort designed to bring together chemical synthesis, cell biology and biotechnology, leading to the discoveries of new agents eliciting unique and unprecedented cell-regulatory profiles.